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Rahul Kharbanda Group

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Jeremiah Hall
Jeremiah Hall

A1 - Like A Rose


You treat me like a roseYou give me room to growYou shone the light of love on meAnd gave me air so I can breatheYou open doors that closeIn a world where anything goesYou give me strength so I stand tallWithin this bed of earthJust like a rose




A1 - Like A Rose



You treat me like a roseYou give me room to growYou shone the light of love on meAnd gave me air so I can breatheYou open doors I closeIn a world where anything goesYou give me strength so I stand tallWithin this bed of earthJust like a rose


A-like and non-A-like rabbits were injected with human group A1 erythrocytes. The rabbit sera were examined serologically for their hemagglutination patterns with human red cells of groups A1 and A2 before and after sequential adsorption with human group O, B and A2 erythrocytes. The A-like rabbits produced specific anti-A1 heteroagglutinins that resisted further adsorptions with group A2 cells. The tissues of A-like rabbits obviously do not contain antigenic configurations equivalent to those on human group A1 erythrocytes. Cross-reacting antibodies were also formed, by the non-A-like rabbits especially, as evidenced by the increased titer of agglutinins reactive with human group B red cells.


Bone metastasis is a leading cause of morbidity and mortality in prostate cancer (PCa). While cancer stem-like cells have been implicated as a cell of origin for PCa metastases, the pathways which enable metastatic development at distal sites remain largely unknown. In this study, we illuminate pathways relevant to bone metastasis in this disease. We observed that cyclin A1 (CCNA1) protein expression was relatively higher in PCa metastatic lesions in lymph node, lung, and bone/bone marrow. In both primary and metastatic tissues, cyclin A1 expression was also correlated with aromatase (CYP19A1), a key enzyme that directly regulates the local balance of androgens to estrogens. Cyclin A1 overexpression in the stem-like ALDHhigh subpopulation of PC3M cells, one model of PCa, enabled bone marrow integration and metastatic growth. Further, cells obtained from bone marrow metastatic lesions displayed self-renewal capability in colony forming assays. In the bone marrow, Cyclin A1 and aromatase enhanced local bone marrow-releasing factors, including androgen receptor, estrogen and matrix metalloproteinase MMP9 and promoted the metastatic growth of PCa cells. Moreover, ALDHhigh tumor cells expressing elevated levels of aromatase stimulated tumor/host estrogen production and acquired a growth advantage in the presence of host bone marrow cells. Overall, these findings suggest that local production of steroids and MMPs in the bone marrow may provide a suitable microenvironment for ALDHhigh PCa cells to establish metastatic growths, offering new approaches to therapeutically target bone metastases.


(1) you can add cells and delete rows as you like in the lawyer sheets. In the Helptable, I always start from cell A2 and add as many rows as there are. You should not leave any free rows between the data, otherwise they will also be displayed in the consolidation sheet.


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Bevis said anyone who feels like they have been exposed or attended an event where someone tested positive can get tested if they are asymptomatic, but they should definitely get tested if they develop symptoms. 041b061a72


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